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Flavonoids for natural detoxification

Flavonoids for natural detoxification

Flavonoids for natural detoxification SS, Rorvik DR, Flavonoisd. Geoghegan F, Wong R, Rabie A. J Clin Investig. This physical property directly limits the absorption of quercetin in the body

Flavonoids for natural detoxification -

In addition, Fe II is rapidly oxidised to Fe III in the presence or absence of the polyphenol and the oxidation rate constants of the ferrous complexes have been demonstrated to be intimately related to the anti-oxidant properties of the flavonoid compounds [ 82 ].

These features are reflected by the oxidant and antioxidant biomarkers. The catalase activity was also reinstated at initial levels for quercetin and rutin pre-treatments. Cu II stands in contrast with Fe II. Cu was also shown to decrease the glutathione levels [ 85 ] as also evidenced in the present study Fig 7.

Carbonyl proteins levels seem to be, however, more altered than MDA. The Cu-quercetin complexation was suggested to occur via the 4-keto group of the C-ring with additional involvement of the 3OH or 5OH group [ 74 ].

Complexation of Cu II by catecholate-based ligands was demonstrated to favour metal reduction and lead to more deleterious Cu I cations [ 86 ]. For instance, it was shown that during the Cu-initiated autoxidation of quercetin, H 2 O 2 rapidly accumulates.

Furthermore, the main autoxidation products of quercetin was shown to be the solvent adducts on the p-quinonemethide intermediate formed upon two-electron oxidation of quercetin [ 80 ].

Increasing quercetin concentration up to μM improved the redox status of the treated RBCs. This can be related to the nature of the Cu complexes with these two polyphenols. It was proposed that for polyphenols exhibiting both antioxidant and prooxidant activity, a redox-cycling pathway may occur at low concentrations when there is not enough polyphenols to scavenge radicals, and at higher concentrations radicals are scavenged at once [ 87 ].

It is the most common non-redox transition metal [ 89 ] and its total concentration in human plasma is ranging between 12 and 20 mM [ 90 ]. However, its free concentration is several orders of magnitude lower, mainly due to binding by albumin [ 91 , 92 ]. Specialized proteins are responsible for controlling Zn import and export, as well as its intracellular distribution [ 93 ].

This is most likely due to the less stable complexes that can be formed with the three flavonoids considered in this work. Flavonoids protection was efficient at a concentration of μM. In summary, flavonoids possessing a catecholate group are more likely to interact with metals especially Fe.

Our results showed that at high Fe and Zn concentrations, flavonoids were able to inhibit their hemolytic activity. However, when interacting with Cu a weak antioxidant effect was observed at high metal concentrations, and prooxidant activity was observed at low concentrations.

This was corroborated by the data obtained with oxidative stress markers. Flavonoids are then able to exhibit both prooxidant and antioxidant activities depending on their concentration and on the metal concentration.

A Absorption spectra, B absorption electronic spectra, and C complex formation evolution as a function of the [Fe NTA ] 0. D Electrospray mass spectra of quercetin noted LH 5 ferric complex in the presence of NTA. D Electrospray mass spectra of rutin noted LH 4 ferric complex in the presence of NTA.

D Electrospray mass spectra of quercetin3OH noted LH ferric complex in the presence of NTA. A Absorption spectra, B absorption electronic spectra, and C complex formation evolution as a function of the [Cu II ] 0.

A Absorption spectra, B absorption electronic spectra, and C complex formation evolution as a function of the [Zn II ] 0. D Electrospray mass spectra of the rutin noted LH 4 Cu II complex.

The Ministry of Foreign Affairs of the French Government, the Ministry of Higher Education and Research of the Algerian Government and the French Foreign Office Campus France are acknowledged for facilitating the scientific collaboration between the University of Tlemcen University Abou Bekr Belkaid and the CNRS UMR Conceptualization: NMS HM ME.

Data curation: SAC. Formal analysis: SAC NMS ME. Funding acquisition: NMS ME. Investigation: SAC FB BB AC.

Methodology: SAC NMS HM ME. Project administration: NMS ME. Resources: NMS HM ME. Software: SAC ME. Supervision: NMS HM ME. Validation: SAC NMS HM ME. Visualization: SAC NMS HM ME. Writing — original draft: SAC NMS HM ME. Browse Subject Areas? Click through the PLOS taxonomy to find articles in your field.

Article Authors Metrics Comments Media Coverage Reader Comments Figures. Introduction Flavonoids that belong to the polyphenols family are secondary plant metabolites and one the most occurring groups of phytochemicals.

Download: PPT. Fig 1. Basic structure of flavonoids and general chemical structure of different flavonoids. Fig 2. Absorption spectrophotometric Titrations of the Polyphenols by FeNTA, Cu II and Zn II at pH 7.

Preparation of the Flavonoids and Metal Solutions for Biochemical Analyses Solutions of flavonoids and metals were prepared immediately before use. Preparation of Human Blood Samples Human RBCs were separated from heparinized blood that was drawn from a healthy donor. Statistical Methods The results are presented as means ± standard deviations of at least three repetitions.

Results Absorption and Stabilities of metal Complexes In the human body, Fe III is mainly exposed to neutral pH pH ~7.

Fig 3. Table 1. Antioxidant Properties Table 2 summarizes the results of the antiradical activities obtained using the 2,2-diphenylpicrylhydrazyl DPPH radical scavenging assay.

Table 2. Effective concentration EC 50 ±SD of the investigated flavonoids and standard i. Fig 4. In vitro Activities We then investigated the effect of metal addition on the hemolysis of RBC membranes Fig 5. Fig 5. Fig 6. Fig 7. Discussion In this study, red blood cells RBCs were subjected to in vitro extracellular metal ion-induced hemolysis.

Conclusion In summary, flavonoids possessing a catecholate group are more likely to interact with metals especially Fe. Supporting Information. S1 Fig. Absorption spectrophotometric titration of quercetin by FeNTA. s DOCX. S2 Fig. Absorption spectrophotometric titration of rutin by FeNTA.

S3 Fig. Absorption spectrophotometric titration of quercetin3OH by FeNTA. S4 Fig. Absorption spectrophotometric titration of quercetin35OH by FeNTA. S5 Fig. Absorption spectrophotometric titration of quercetin by Cu II.

S6 Fig. Absorption spectrophotometric titration of quercetin by Zn II. S7 Fig. Absorption spectrophotometric titration of rutin by Cu II.

S8 Fig. Absorption spectrophotometric titration of rutin by Zn II. S9 Fig. Acknowledgments The Ministry of Foreign Affairs of the French Government, the Ministry of Higher Education and Research of the Algerian Government and the French Foreign Office Campus France are acknowledged for facilitating the scientific collaboration between the University of Tlemcen University Abou Bekr Belkaid and the CNRS UMR Author Contributions Conceptualization: NMS HM ME.

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Sakihama, N. Recent studies have revealed that dietary flavonoids are potent radical scavengers, acting in a manner similar to ascorbate and α--tocopherol. However, it is still not clear whether flavonoids have a similar antioxidative function in plants. We examined the possibility that flavonoids could function as stress protectants in plant cells by scavenging H2O2.

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Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Journal Article. Flavonoid-Peroxidase Reaction as a Detoxification Mechanism of Plant Cells against H2O2.

Yamasaki , H. Laboratory of Cell and Functional Biology, College of Science, University of the Ryukyus, Nishihara, Okinawa —01, Japan.

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For more information about Natural appetite suppressant effects Subject Dtoxification, click here. The impact Flavonoids for natural detoxification these compounds against Flavonids toxicity detoxificatin studied as well as their antiradical activities with DPPH assay. However, Weight management coaching Cu showed Oats for skin health weak antioxidant effect at the highest flavonoid concentration μMwhile a prooxidant effect was observed at the lowest flavonoid concentration μM. This study reveals that flavonoids have both prooxidant and antioxidant activity depending on the nature and concentration of the flavonoids and metal ions. Citation: Cherrak SA, Mokhtari-Soulimane N, Berroukeche F, Bensenane B, Cherbonnel A, Merzouk H, et al. PLoS ONE 11 10 : e Quercetin belongs to a group of plant pigments called flavonoids that give many fruits, Flavonoidx, and Healthy chia seeds their colors. Flavonoids, such as Flavonolds, are antioxidants. They scavenge particles in the body known as free radicals which damage cell membranes, tamper with DNA, and even cause cell death. Antioxidants can neutralize free radicals. They may reduce or even help prevent some of the damage free radicals cause. Flavonoids for natural detoxification

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