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Flavonoids for natural detoxification

Flavonoids for natural detoxification

Flavonoids for natural detoxification SS, Rorvik DR, Flavonoisd. Geoghegan F, Wong R, Rabie A. J Clin Investig. This physical property directly limits the absorption of quercetin in the body

Flavonoids for natural detoxification -

In addition, Fe II is rapidly oxidised to Fe III in the presence or absence of the polyphenol and the oxidation rate constants of the ferrous complexes have been demonstrated to be intimately related to the anti-oxidant properties of the flavonoid compounds [ 82 ].

These features are reflected by the oxidant and antioxidant biomarkers. The catalase activity was also reinstated at initial levels for quercetin and rutin pre-treatments. Cu II stands in contrast with Fe II. Cu was also shown to decrease the glutathione levels [ 85 ] as also evidenced in the present study Fig 7.

Carbonyl proteins levels seem to be, however, more altered than MDA. The Cu-quercetin complexation was suggested to occur via the 4-keto group of the C-ring with additional involvement of the 3OH or 5OH group [ 74 ].

Complexation of Cu II by catecholate-based ligands was demonstrated to favour metal reduction and lead to more deleterious Cu I cations [ 86 ]. For instance, it was shown that during the Cu-initiated autoxidation of quercetin, H 2 O 2 rapidly accumulates.

Furthermore, the main autoxidation products of quercetin was shown to be the solvent adducts on the p-quinonemethide intermediate formed upon two-electron oxidation of quercetin [ 80 ].

Increasing quercetin concentration up to μM improved the redox status of the treated RBCs. This can be related to the nature of the Cu complexes with these two polyphenols. It was proposed that for polyphenols exhibiting both antioxidant and prooxidant activity, a redox-cycling pathway may occur at low concentrations when there is not enough polyphenols to scavenge radicals, and at higher concentrations radicals are scavenged at once [ 87 ].

It is the most common non-redox transition metal [ 89 ] and its total concentration in human plasma is ranging between 12 and 20 mM [ 90 ]. However, its free concentration is several orders of magnitude lower, mainly due to binding by albumin [ 91 , 92 ]. Specialized proteins are responsible for controlling Zn import and export, as well as its intracellular distribution [ 93 ].

This is most likely due to the less stable complexes that can be formed with the three flavonoids considered in this work. Flavonoids protection was efficient at a concentration of μM. In summary, flavonoids possessing a catecholate group are more likely to interact with metals especially Fe.

Our results showed that at high Fe and Zn concentrations, flavonoids were able to inhibit their hemolytic activity. However, when interacting with Cu a weak antioxidant effect was observed at high metal concentrations, and prooxidant activity was observed at low concentrations.

This was corroborated by the data obtained with oxidative stress markers. Flavonoids are then able to exhibit both prooxidant and antioxidant activities depending on their concentration and on the metal concentration.

A Absorption spectra, B absorption electronic spectra, and C complex formation evolution as a function of the [Fe NTA ] 0. D Electrospray mass spectra of quercetin noted LH 5 ferric complex in the presence of NTA. D Electrospray mass spectra of rutin noted LH 4 ferric complex in the presence of NTA.

D Electrospray mass spectra of quercetin3OH noted LH ferric complex in the presence of NTA. A Absorption spectra, B absorption electronic spectra, and C complex formation evolution as a function of the [Cu II ] 0.

A Absorption spectra, B absorption electronic spectra, and C complex formation evolution as a function of the [Zn II ] 0. D Electrospray mass spectra of the rutin noted LH 4 Cu II complex.

The Ministry of Foreign Affairs of the French Government, the Ministry of Higher Education and Research of the Algerian Government and the French Foreign Office Campus France are acknowledged for facilitating the scientific collaboration between the University of Tlemcen University Abou Bekr Belkaid and the CNRS UMR Conceptualization: NMS HM ME.

Data curation: SAC. Formal analysis: SAC NMS ME. Funding acquisition: NMS ME. Investigation: SAC FB BB AC.

Methodology: SAC NMS HM ME. Project administration: NMS ME. Resources: NMS HM ME. Software: SAC ME. Supervision: NMS HM ME. Validation: SAC NMS HM ME. Visualization: SAC NMS HM ME. Writing — original draft: SAC NMS HM ME. Browse Subject Areas? Click through the PLOS taxonomy to find articles in your field.

Article Authors Metrics Comments Media Coverage Reader Comments Figures. Introduction Flavonoids that belong to the polyphenols family are secondary plant metabolites and one the most occurring groups of phytochemicals.

Download: PPT. Fig 1. Basic structure of flavonoids and general chemical structure of different flavonoids. Fig 2. Absorption spectrophotometric Titrations of the Polyphenols by FeNTA, Cu II and Zn II at pH 7.

Preparation of the Flavonoids and Metal Solutions for Biochemical Analyses Solutions of flavonoids and metals were prepared immediately before use. Preparation of Human Blood Samples Human RBCs were separated from heparinized blood that was drawn from a healthy donor. Statistical Methods The results are presented as means ± standard deviations of at least three repetitions.

Results Absorption and Stabilities of metal Complexes In the human body, Fe III is mainly exposed to neutral pH pH ~7.

Fig 3. Table 1. Antioxidant Properties Table 2 summarizes the results of the antiradical activities obtained using the 2,2-diphenylpicrylhydrazyl DPPH radical scavenging assay.

Table 2. Effective concentration EC 50 ±SD of the investigated flavonoids and standard i. Fig 4. In vitro Activities We then investigated the effect of metal addition on the hemolysis of RBC membranes Fig 5. Fig 5. Fig 6. Fig 7. Discussion In this study, red blood cells RBCs were subjected to in vitro extracellular metal ion-induced hemolysis.

Conclusion In summary, flavonoids possessing a catecholate group are more likely to interact with metals especially Fe. Supporting Information. S1 Fig. Absorption spectrophotometric titration of quercetin by FeNTA. s DOCX. S2 Fig. Absorption spectrophotometric titration of rutin by FeNTA.

S3 Fig. Absorption spectrophotometric titration of quercetin3OH by FeNTA. S4 Fig. Absorption spectrophotometric titration of quercetin35OH by FeNTA. S5 Fig. Absorption spectrophotometric titration of quercetin by Cu II.

S6 Fig. Absorption spectrophotometric titration of quercetin by Zn II. S7 Fig. Absorption spectrophotometric titration of rutin by Cu II.

S8 Fig. Absorption spectrophotometric titration of rutin by Zn II. S9 Fig. Acknowledgments The Ministry of Foreign Affairs of the French Government, the Ministry of Higher Education and Research of the Algerian Government and the French Foreign Office Campus France are acknowledged for facilitating the scientific collaboration between the University of Tlemcen University Abou Bekr Belkaid and the CNRS UMR Author Contributions Conceptualization: NMS HM ME.

References 1. Correa J, Souza I, Ladeira A, Young M, Aragushi M. Allelopathic potential of Eupatorium maximiliani Schrad. Allelopathy J. View Article Google Scholar 2. Ignat I, Volf I, Popa VI. A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables.

Food Chemistry. Geoghegan F, Wong R, Rabie A. Inhibitory effect of quercetin on periodontal pathogens in vitro. Phytotherapy Research. Hassan S, Mathesius U.

The role of flavonoids in root—rhizosphere signalling: opportunities and challenges for improving plant—microbe interactions. Journal of experimental botany. Lourenço RMDC, da Silva Melo P, de Almeida ABA.

Flavonoids as antifungal agents. Antifungal Metabolites from Plants: Springer; Salunke B, Kotkar H, Mendki P, Upasani S, Maheshwari V. Efficacy of flavonoids in controlling Callosobruchus chinensis L.

Coleoptera: Bruchidae , a post-harvest pest of grain legumes. Crop Protection. View Article Google Scholar 7. Moon YJ, Wang X, Morris ME. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.

Toxicology in vitro. Balasundram N, Sundram K, Samman S. Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food chemistry. View Article Google Scholar 9.

Hayder N, Bouhlel I, Skandrani I, Kadri M, Steiman R, Guiraud P, et al. In vitro antioxidant and antigenotoxic potentials of myricetino-galactoside and myricetino-rhamnoside from Myrtus communis: modulation of expression of genes involved in cell defence system using cDNA microarray.

Knekt P, Kumpulainen J, Järvinen R, Rissanen H, Heliövaara M, Reunanen A, et al. Flavonoid intake and risk of chronic diseases. The American journal of clinical nutrition. Chvátalová K, Slaninová I, Březinová L, Slanina J. Influence of dietary phenolic acids on redox status of iron: Ferrous iron autoxidation and ferric iron reduction.

View Article Google Scholar Pisoschi AM, Pop A. The role of antioxidants in the chemistry of oxidative stress: a review. European journal of medicinal chemistry. Agati G, Azzarello E, Pollastri S, Tattini M. Flavonoids as antioxidants in plants: location and functional significance. Plant Science.

Gil ES, Cout RO. Flavonoid electrochemistry: a review on the electroanalytical applications. Revista Brasileira de Farmacognosia. Pietta P-G. Flavonoids as antioxidants. Journal of natural products. Robak J, Gryglewski RJ. Flavonoids are scavengers of superoxide anions.

Biochemical pharmacology. Birt DF, Hendrich S, Wang W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Chen K, Thomas SR, Keaney JF. Beyond LDL oxidation: ROS in vascular signal transduction.

Free Radical Biology and Medicine. Baccarin T, Mitjans M, Lemos-Senna E, Vinardell MP. Protection against oxidative damage in human erythrocytes and preliminary photosafety assessment of Punica granatum seed oil nanoemulsions entrapping polyphenol-rich ethyl acetate fraction.

Toxicology in Vitro. Wilms LC, Kleinjans JC, Moonen EJ, Briedé JJ. Discriminative protection against hydroxyl and superoxide anion radicals by quercetin in human leucocytes in vitro.

Procházková D, Boušová I, Wilhelmová N. Antioxidant and prooxidant properties of flavonoids. Burda S, Oleszek W. Antioxidant and antiradical activities of flavonoids. Journal of Agricultural and Food Chemistry. Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships.

The Journal of nutritional biochemistry. Bourassa P, Côté R, Hutchandani S, Samson G, Tajmir-Riahi H-A. The effect of milk alpha-casein on the antioxidant activity of tea polyphenols.

Journal of Photochemistry and Photobiology B: Biology. Nijveldt RJ, Van Nood E, Van Hoorn DE, Boelens PG, Van Norren K, Van Leeuwen PA. Flavonoids: a review of probable mechanisms of action and potential applications. Kim G-N, Kwon Y-I, Jang H-D. Rescuing hepatocytes from iron-catalyzed oxidative stress using vitamins B1 and B6.

Hippeli S, Elstner EF. FEBS letters. Prousek J. Fenton chemistry in biology and medicine. Pure and applied chemistry. Pham AN, Xing G, Miller CJ, Waite TD. Fenton-like copper redox chemistry revisited: hydrogen peroxide and superoxide mediation of copper-catalyzed oxidant production.

Journal of catalysis. Robbins MH, Drago RS. Activation of hydrogen peroxide for oxidation by copper II complexes. Journal of Catalysis. Leopoldini M, Russo N, Toscano M. The molecular basis of working mechanism of natural polyphenolic antioxidants. Psotová J, Lasovsky J, Vicar J. Metal-chelating properties, electrochemical behavior, scavenging and cytoprotective activities of six natural phenolics.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. Dehghan G, Khoshkam Z. Tin II —quercetin complex: Synthesis, spectral characterisation and antioxidant activity. Pasban Ziyarat F, Asoodeh A, Sharif Barfeh Z, Pirouzi M, Chamani J.

Probing the interaction of lysozyme with ciprofloxacin in the presence of different-sized Ag nano-particles by multispectroscopic techniques and isothermal titration calorimetry. Journal of Biomolecular Structure and Dynamics. Mabile L, Piolot A, Boulet L, Fortin L-J, Doyle N, Rodriguez C, et al.

Kabel AM. Free Radicals and Antioxidants: Role of Enzymes and Nutrition. World Journal of Nutrition and Health. Delmas-Beauvieux M, Peuchant E, Dumon M, Receveur M, Le Bras M, Clerc M. Relationship between red blood cell antioxidant enzymatic system status and lipoperoxidation during the acute phase of malaria.

Clinical biochemistry. Rodriguez-Mateos A, Vauzour D, Krueger CG, Shanmuganayagam D, Reed J, Calani L, et al. Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update.

Archives of toxicology. Moosavi-Movahedi AA, Hakimelahi S, Chamani J, Khodarahmi GA, Hassanzadeh F, Luo F-T, et al.

Design, synthesis, and anticancer activity of phosphonic acid diphosphate derivative of adenine-containing butenolide and its water-soluble derivatives of paclitaxel with high antitumor activity.

Davis AL, Cai Y, Davies AP, Lewis J. Magnetic resonance in Chemistry. Han Y, Ding Y, Xie D, Hu D, Li P, Li X, et al. Design, synthesis, and antiviral activity of novel rutin derivatives containing 1, 4-pentadienone moiety. JURD L. Selective Alkylation of Polyphenols.

The Use of Diphenylmethylene as a Protective Grouping for o-Dihydroxyflavones. The Journal of Organic Chemistry.

Shi Z-H, Li N-G, Tang Y-P, Yang J-P, Duan J-A. Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors.

Méthodes d'Analyses Complexométriques avec les Titriplex EM, Darmstadt. Bastian R, Weberling R, Palilla F. Determination of iron by ultraviolet spectrophotometry.

Analytical Chemistry. Raymond K. Tragic consequence with acetonitrile adduct. Gampp H, Maeder M, Meyer CJ, Zuberbühler AD. Calculation of equilibrium constants from multiwavelength spectroscopic data—II: SPECFIT: two user-friendly programs in basic and standard FORTRAN Maeder M, Zuberbuehler AD.

Nonlinear least-squares fitting of multivariate absorption data. Marquardt DW. An algorithm for least-squares estimation of nonlinear parameters.

Journal of the society for Industrial and Applied Mathematics. Goupy P, Dufour C, Loonis M, Dangles O.

Quantitative kinetic analysis of hydrogen transfer reactions from dietary polyphenols to the DPPH radical. Tanzadehpanah H, Asoodeh A, Chamani J. An antioxidant peptide derived from Ostrich Struthio camelus egg white protein hydrolysates. Food research international.

Memarpoor-Yazdi M, Asoodeh A, Chamani J. A novel antioxidant and antimicrobial peptide from hen egg white lysozyme hydrolysates. Journal of Functional Foods. Ghavami S, Asoodeh A, Klonisch T, Halayko AJ, Kadkhoda K, Kroczak TJ, et al.

Journal of cellular and molecular medicine. Fiorani M, Accorsi A, Cantoni O. Human red blood cells as a natural flavonoid reservoir. Free radical research. Ellman GL.

Sakihama, N. Recent studies have revealed that dietary flavonoids are potent radical scavengers, acting in a manner similar to ascorbate and α--tocopherol. However, it is still not clear whether flavonoids have a similar antioxidative function in plants. We examined the possibility that flavonoids could function as stress protectants in plant cells by scavenging H2O2.

Two major flavonoids, quercetin and kaempferol glycosides, were isolated from leaves of the tropical tree Schefflera arboricola Hayata. arboricola leaf extract. Judging from the effects of inhibitors such as KCN, p-chloromercuribenzoate, and 3-amino-1H-1,2,4-triazole, we conclude that guaiacol peroxidase in the soluble fraction catalyzes H2O2-dependent oxidation of flavonols.

In the flavonol-guaiacol peroxidase reaction, ascorbate had the potential to regenerate flavonols by reducing the oxidized product. These results provide further evidence that the flavonoid-peroxidase reaction can function as a mechanism for H2O2 scavenging in plants.

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Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Journal Article. Flavonoid-Peroxidase Reaction as a Detoxification Mechanism of Plant Cells against H2O2.

Yamasaki , H. Laboratory of Cell and Functional Biology, College of Science, University of the Ryukyus, Nishihara, Okinawa —01, Japan.

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For more information about Natural appetite suppressant effects Subject Dtoxification, click here. The impact Flavonoids for natural detoxification these compounds against Flavonids toxicity detoxificatin studied as well as their antiradical activities with DPPH assay. However, Weight management coaching Cu showed Oats for skin health weak antioxidant effect at the highest flavonoid concentration μMwhile a prooxidant effect was observed at the lowest flavonoid concentration μM. This study reveals that flavonoids have both prooxidant and antioxidant activity depending on the nature and concentration of the flavonoids and metal ions. Citation: Cherrak SA, Mokhtari-Soulimane N, Berroukeche F, Bensenane B, Cherbonnel A, Merzouk H, et al. PLoS ONE 11 10 : e Quercetin belongs to a group of plant pigments called flavonoids that give many fruits, Flavonoidx, and Healthy chia seeds their colors. Flavonoids, such as Flavonolds, are antioxidants. They scavenge particles in the body known as free radicals which damage cell membranes, tamper with DNA, and even cause cell death. Antioxidants can neutralize free radicals. They may reduce or even help prevent some of the damage free radicals cause. Flavonoids for natural detoxification

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