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Alpha-lipoic acid uses

Alpha-lipoic acid uses

Coenzyme Q heart health may accept or manage your Appha-lipoic by Metabolic enhancers below, Coenzyme Q heart health your right caid object where legitimate interest is used, or at any time in the privacy policy page. So far, there's no evidence to say whether or not it works. BMI calculations may, for example, overestimate body fat in athletes or in older people.

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The 8 Benefits of Alpha-Lipoic Acid

Alpha-lipoic acid uses -

Supplementation of ALA in children has not been carefully studied. Therefore, it is not recommended for children.

Like many other supplements, ALA is not recommended for people who are pregnant, breastfeeding, or chestfeeding.

Not enough research has been done to understand ALA's effects in these groups. The food you eat will always be your best source of nutrients. If you have a healthy appreciation for vegetables, you may be able to get plenty of ALA from your diet.

ALA can be found in:. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs.

While ALA is considered safe, there are no guidelines directing its use. Most oral supplements are sold in capsule or tablet formulations ranging from milligrams to milligrams.

A dose of milligrams to 1, milligrams daily appears the most common in studies. This is typically divided into three equal doses each day. These numbers are meant only to give you an idea of a possible daily dosage.

It's never wise to follow an arbitrary number or someone else's dosage plan. No two people are alike, and someone else may be dealing with circumstances you are unaware of. Like most nutritional supplements, ALA should be stored in a cool, dry place. Since ALA is not an essential nutrient, there is no recommended amount to get in your diet or through supplements.

There also is no set upper intake limit. If you take too much ALA, you may experience some of the side effects discussed above, but they tend to resolve when the supplement is stopped.

Some studies have found that taking large amounts of ALA can be dangerous. In one reported case, a year-old woman experienced multiple organ failures from too much ALA.

In another, accidental exposure to ALA caused a toddler to experience convulsions. In a third case, a year-old woman experienced tachycardia or a rapid heartbeat, altered mental state, and metabolic acidosis after an intentional overdose of ALA. It is essential to carefully read the ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included.

Review this supplement label with a healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Alpha-lipoic acid is a fatty acid found naturally inside every cell of the human body. Its primary role is to convert blood sugar glucose into energy using oxygen.

Many people use it to help with diabetes, nerve pain, weight loss, heart disease, and primary mitochondrial disorders. Side effects of using ALA appear mild and, when they're not, seem to be caused by taking too much.

Like other supplements, ALA is capable of interacting with other medications. Thus, it's crucial that a healthcare provider understands your full health picture before offering a verdict on whether you can safely use ALA. ALA may help to manage blood sugar associated with diabetes and ease neuropathy pain.

There is less evidence that it helps with weight loss. There is no evidence to confirm that ALA can help you sleep. In fact, insomnia can be a side effect of the supplement.

However, ALA may reduce pain from neuropathy, which may help some people sleep better. ALA has anti-inflammatory properties. However, it does not work in the same way as non-steroidal anti-inflammatory drugs. It may help to reduce systemic inflammation over time, but you will not notice any immediate effects.

An ALA deficiency is practically unheard of. Rare genetic mutations have been described in medical literature in which the body is unable to produce lipoic acid synthase. It is estimated that fewer than one in a million people are affected. Gomes MB, Negrato CA. Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases.

Diabetol Metab Syndr. Mayr JA, Feichtinger RG, Tort F, Ribes A, Sperl W. Lipoic acid biosynthesis defects. J Inherit Metab Dis. Kucukgoncu S, Zhou E, Lucas KB, Tek C. Alpha-lipoic acid ALA as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials.

Obes Rev. Namazi N, Larijani B, Azadbakht L. Alpha-lipoic acid supplement in obesity treatment: a systematic review and meta-analysis of clinical trials. Clinical Nutrition. Vajdi M, Abbasalizad Farhangi M. Int J Clin Pract. Gutin I. In BMI We Trust: Reframing the Body Mass Index as a Measure of Health.

Soc Theory Health. Akbari M, Ostadmohammadi V, Lankarani KB, et al. The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Metab Clin Exp. Rahimlou M, Asadi M, Banaei Jahromi N, Mansoori A.

Alpha-lipoic acid Ala supplementation effect on glycemic and inflammatory biomarkers: a systematic review and meta- analysis. Clinical Nutrition ESPEN. Mahmoudi-Nezhad M, Vajdi M, Farhangi MA. An updated systematic review and dose-response meta-analysis of the effects of α-lipoic acid supplementation on glycemic markers in adults.

Esposito C, Ugo Garzarella E, Santarcangelo C, et al. Safety and efficacy of alpha-lipoic acid oral supplementation in the reduction of pain with unknown etiology: a monocentric, randomized, double-blind, placebo-controlled clinical trial.

Viana MDM, Lauria PSS, Lima AA, Opretzka LCF, Marcelino HR, Villarreal CF. Alpha-lipoic acid as an antioxidant strategy for managing neuropathic pain. Antioxidants Basel. Koh EH, Lee WJ, Lee SA, et al. Effects of alpha-lipoic acid on body weight in obese subjects. On the other hand, suppressing AMPK activity may increase the number of calories your body burns at rest.

Thus, animals who took alpha-lipoic acid burned more calories 6 , 7. An analysis of 12 studies discovered that people who took an alpha-lipoic acid supplement lost an average of 1.

Another analysis of 12 studies found that people who took alpha-lipoic acid lost an average of 2. Though alpha-lipoic acid has properties that may promote weight loss, its overall effect in humans seems negligible.

Diabetes affects more than million adults worldwide A key feature of uncontrolled diabetes is high blood sugar levels.

If left untreated, this can cause health problems, such as vision loss, heart disease, and kidney failure. Other studies in adults with metabolic syndrome have shown that it may reduce insulin resistance and lower fasting blood glucose and HbA1c levels.

Scientists believe that alpha-lipoic acid helps lower blood sugar by promoting processes that can remove fat that has accumulated in muscle cells, which otherwise makes insulin less effective Alpha-lipoic acid has been shown to reduce insulin resistance, improve blood sugar control, ease symptoms of nerve damage, and lower the risk of diabetic retinopathy.

In one human study, scientists found that applying a cream containing alpha-lipoic acid to the skin reduced fine lines, wrinkles, and skin roughness with no side effects Moreover, alpha-lipoic acid raises the levels of other antioxidants, such as glutathione , which help protect against skin damage and may reduce signs of aging 21 , Memory loss is a common concern among older adults.

However, only a handful of studies have investigated alpha-lipoic acid and memory loss-related disorders.

More research is needed before alpha-lipoic acid can be recommended for treatment. This condition is characterized by numbness or tingling in the hand caused by a pinched nerve Moreover, taking alpha-lipoic acid before and after surgery for carpal tunnel syndrome has been shown to improve recovery outcomes Studies have also discovered that alpha-lipoic acid may ease symptoms of diabetic neuropathy, which is nerve pain caused by uncontrolled diabetes 14 , Chronic inflammation is linked to several diseases, including cancer and diabetes.

In an analysis of 11 studies, alpha-lipoic acid significantly lowered levels of the inflammatory marker C-reactive protein CRP in adults with high levels of CRP In test-tube studies, alpha-lipoic acid has reduced markers of inflammation, including NF-kB, ICAM-1, VCAM-1, MMP-2, MMP-9, and IL-6 30 , 31 , 32 , Heart disease is responsible for one in four deaths in America Research from a combination of lab, animal, and human studies has shown that the antioxidant properties of alpha-lipoic acid may lower several heart disease risk factors.

First, antioxidant properties allow alpha-lipoic acid to neutralize free radicals and reduce oxidative stress, which is linked to damage that can increase heart disease risk Alpha-lipoic acid has strong antioxidant properties, which may reduce inflammation and skin aging, promote healthy nerve function, lower heart disease risk factors, and slow the progression of memory loss disorders.

In some cases, people may experience mild symptoms like nausea , rashes, or itching. However, research shows that adults can take up to 2, mg without harmful side effects Furthermore, animal research has found that extremely high doses of alpha-lipoic acid may promote oxidation, alter liver enzymes, and place strain on liver and breast tissue 38 , To date, very few studies have looked at the safety of alpha-lipoic acid in children and pregnant women.

These populations should not take it unless advised to do so by their healthcare provider. If you have diabetes, consult your healthcare provider before taking alpha-lipoic acid, as it may interact with other medicines that help lower blood sugar levels.

Alpha-lipoic acid is generally safe with little to no side effects. In some instances, people may experience mild symptoms, such as nausea, rashes, or itching. Good sources of alpha-lipoic acid include 3 :.

Alpha-lipoic acid is also available as a supplement and can be found in many health stores and online.

Supplements can contain up to 1, times more alpha-lipoic acid than foods 3. This function may protect nerve tissue from damage. Conditions, such as diabetes, may be helped by antioxidants such as ALA.

There is no evidence for a specific dose. Always talk with your healthcare provider before taking any supplements. Women who are pregnant or breastfeeding should talk with a healthcare provider before taking any supplements.

There are no known food or medicine interactions. If you have diabetes and use ALA, work closely with your healthcare provider and closely keep track of your blood sugar levels. ALA may reduce the amount of insulin or oral diabetes medicines that are needed. Use it cautiously. Search Encyclopedia.

Coronavirus COVID : Alpha-lipoiic Updates Visitation Acld Visitation Policies Visitation Policies Visitation Policies Visitation Alpha-lipolc COVID Fungus-resistant technology Vaccine Information Vaccine Information Alpha-lipoic acid uses Information. Afid lipoic acid ALA is an antioxidant. It is quickly absorbed from the gastrointestinal tract. It dissolves in both water and fat in the body. ALA is frequently used to treat diabetic neuropathy. This is a sensory change that includes stinging, burning, pain, and numbness in parts of the skin. Alpha-lipoic acid uses Alpha-lipoic acid ALA is a Alpha-lipoif fatty acid. Your body makes its own ALA, but Alpha-lipoic acid uses Aloha-lipoic also available in certain foods and as Metabolism and sleep supplement. ALA supplements Allpha-lipoic provide health benefits, such as aiding in weight loss and managing blood sugar, but more research needs to be done to support its use. This article reviews the potential uses of ALA and also covers side effects and possible interactions. Supplement use should be individualized and vetted by a healthcare provider. No supplement is intended to treat, cure, or prevent disease.

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