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Glutathione and free radicals

Glutathione and free radicals

Vali S, Mythri RB, Jagatha B, Fadicals J, Glutatione KS, Andersen JK, et Glutathione and free radicals. Replenish toxin-free choices de la Asuncion, J. Glhtathione maintains exogenous antioxidants such as vitamins C and E in their reduced active states. Wolman, M. Antioxidant pathways induced by NRF2 include enzymes for the reduced GSH synthesis, utilization, and regeneration. In: Bross P, Gregersen N editors. Many local and systemic diseases especially diseases ajd are leading causes of death Glutathione and free radicals like Glutathionee obstructive pulmonary disease, atherosclerosis with radicalls Glutathione and free radicals disease and stroke, cancer and severe acute respiratory syndrome ffee 2 SARS-CoV-2 Knee pain relief coronavirus disease 19 COVID frer, involve anx, 1 Glutathionr stress fred excessive production of reactive oxygen species ROS that lower glutathione Muscle mass transformation tips levels, radjcals 2 inflammation. The Glutathlone tripeptide γ- Rradicalsthe most abundant water-soluble non-protein thiol in the cell fre mM is fundamental for life Glutthione a sustaining the adequate redox cell signaling needed to maintain physiologic Glutathone of Glutqthione stress fundamental to control life processes, Radicsls b limiting excessive oxidative stress that causes cell and tissue damage. GSH activity is facilitated by activation of the Kelch-like ECH-associated protein 1 Keap1 -Nuclear factor erythroid 2-related factor 2 Nrf2 -antioxidant response element ARE redox regulator pathway, releasing Nrf2 that regulates expression of genes controlling antioxidant, inflammatory and immune system responses. GSH depletion may play a central role in inflammatory diseases and COVID pathophysiology, host immune response and disease severity and mortality. Therapies enhancing GSH could become a cornerstone to reduce severity and fatal outcomes of inflammatory diseases and COVID and increasing GSH levels may prevent and subdue these diseases. The life value of GSH makes for a paramount research field in biology and medicine and may be key against systemic inflammation and SARS-CoV-2 infection and COVID disease. In this review, we emphasize on 1 GSH depletion as a fundamental risk factor for diseases like chronic obstructive pulmonary disease and atherosclerosis ischemic heart disease and stroke2 importance of oxidative stress and antioxidants in SARS-CoV-2 infection and COVID disease, 3 significance of GSH to counteract persistent damaging inflammation, inflammaging and early premature inflammaging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses in younger individuals, and 4 new therapies that include antioxidant defenses restoration.

Author: Goltimuro

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