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Alpha-lipoic acid for nerve pain

Alpha-lipoic acid for nerve pain

And because ALA is Alpha-pipoic combined with other compounds, fkr not Antiviral healing properties known how Alpha-lipoic acid for nerve pain Alphx-lipoic it has on its own. Philadelphia, PA: Elsevier Saunders; The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Alpha-lipoic acid for nerve pain

Alpha-lipoic acid for nerve pain -

ALA may reduce tissue damage caused by long-term exposure to high levels of oxygen. ALA has been studied as a treatment for alcohol-related liver disease. However, benefits have not been observed at this time. For alcoholic liver disease, milligrams of ALA has been taken by mouth in three divided doses daily for up to 24 weeks.

As an antioxidant, , milligrams of ALA has been taken by mouth daily for four weeks to six months. Additionally, , milligrams of ALA has been taken by mouth in two or three divided doses for days. For cognitive function associated with HIV, milligrams of ALA has been taken by mouth twice daily for 10 weeks.

For glaucoma damaged optic nerve , milligrams of ALA taken by mouth for one month showed improvement over 75 milligrams of ALA taken by mouth for two months. For HIV patients on antiretroviral therapy, milligrams of ALA has been taken by mouth three times daily for six months. For impaired glucose tolerance, milliliters of saline solution containing milligrams of ALA was injected once daily for up to three weeks.

Additionally, milliliters of saline containing milligrams of ALA has been used as a single dose. For improving blood flow, , milligrams of ALA has been taken by mouth. Additionally, milligrams of ALA in milliliters of saline has been injected for up to three weeks.

For lipid lowering effects, milligrams of ALA has been taken by mouth daily for up to16 weeks. A dosage of milligrams was also taken by mouth daily for four weeks. A dosage of milligrams of ALA in milliliters of saline has been injected into a vein daily for 14 days.

For neuropathy nerve damage , , milligrams of ALA has been taken by mouth daily in divided doses from 19 days to four years. A dose of , milligrams of ALA has been injected into a vein for up to four weeks. For pain burning mouth syndrome , milligrams of ALA has been taken by mouth daily for up to three months.

For peripheral artery disease, milligrams of ALA has been taken by mouth daily in two divided doses for three months. For prevention of tissue damage after restored blood flow, milligrams of ALA in 50 milliliters of sodium chloride has been injected into a vein. For rheumatoid arthritis, milligrams of ALA has been taken by mouth three times daily for 12 weeks.

For sciatica pain from compressed nerve , milligrams of ALA has been taken by mouth daily for 60 days. For steatohepatitis fatty liver , milligrams of ALA has been taken by mouth twice or thrice daily for months. For type 2 diabetes, , milligrams of ALA has been taken by mouth daily for up to two years.

Doses of , milligrams of ALA in saline or sodium chloride have been injected into a vein for up to three weeks. For weight loss, mg of ALA has been taken by mouth three times daily for 20 weeks.

Additionally, 1, milligrams of ALA has been taken daily by mouth for 12 weeks. For wound healing in people undergoing hyperbaric oxygen therapy, milligrams of ALA has been taken by mouth before exposure to oxygen and immediately after therapy.

Then, patients took milligrams by mouth twice daily for the next 30 treatments. For children receiving radiation injuries, milligrams of ALA has been used daily for four weeks.

Background Alpha-lipoic acid ALA is made naturally in the body and may protect against cell damage in a variety of conditions. ALA appears to be generally well tolerated, with minimal adverse effects. A Type 2 diabetes Several studies have shown that ALA may help control and improve blood sugar levels.

A Altitude sickness Antioxidants that included ALA had mixed effects on altitude sickness. C Alzheimer's disease Early research shows mixed results regarding ALA for brain protection. C Antioxidant ALA may increase the production of glutathione and help repair cell damage.

C Bone density Overall evidence of ALA for improving bone mineral density is lacking, although ALA has increased density in a specific hip bone. C Cancer Overall evidence of ALA for preventing cancer progression is currently lacking.

C Carpal tunnel syndrome Early research suggests that ALA and gamma-linolenic acid may benefit symptoms of carpal tunnel syndrome, particularly in the early stages of the disease. C Cognitive function associated with HIV ALA has been studied as a treatment for cognitive impairment problems with mental function caused by nerve damage in HIV patients.

C Glaucoma increased eye pressure ALA may protect the eye from excess pressure, but more research is needed to evaluate ALA's long-term effect. C Heart disease prevention In early research, ALA and other antioxidants had mixed effects on blood pressure.

C Heart failure Antioxidants that included ALA improved some measurements of blood flow. C Heart muscle protection during heart surgery Early research shows that antioxidants, including ALA, may benefit people undergoing cardiac surgery.

C High blood pressure The effect of ALA on blood pressure in unclear. C HIV patients on antiretroviral therapy In HIV patients on antiretroviral therapy, ALA improved white blood cell function. C Improving blood flow endothelial dysfunction ALA has shown mixed results for improving blood flow.

C Inflammation The effects of ALA on inflammation markers are unclear. C Ischemia-reperfusion injury protection prevention of tissue damage after restored blood flow ALA may prevent tissue damage after restored blood flow in the liver.

C Kidney disease ALA may improve the blood vessel lining function, possibly benefiting patients with end-stage kidney disease. C Lipid lowering effects ALA has shown mixed results in reducing cholesterol levels.

C Migraine ALA may help prevent migraines. Further research is needed to confirm these results. C Mitochondrial diseases Research investigating the effect of ALA for mitochondrial diseases problems with cell energy is limited. C Pain burning mouth syndrome ALA has shown mixed results as a treatment for burning mouth syndrome, a condition that causes the mouth to feel hot or tingly.

C Peripheral artery disease ALA may reduce pain associated with exercise in people with peripheral artery disease. C Radiation injuries Limited research suggests that ALA may be beneficial for people exposed to high levels of radiation. C Rheumatoid arthritis Early research suggests that ALA acid lacks effects on symptoms of rheumatoid arthritis and inflammatory mediators.

C Schizophrenia Early research suggests that ALA may reduce some adverse effects of antipsychotic drugs. C Sciatica pain from compressed nerve The antioxidant effects of ALA may aid recovery of nerve function and pain reduction. C Skin aging Early research shows that a skin cream with ALA may help improve signs of skin aging.

C Skin pigmentation disorders Antioxidants with ALA may improve the effectiveness of treatment for skin pigmentation. C Steatohepatitis fatty liver ALA may reduce liver size and reduce other symptoms of a fatty liver. C Weight loss Research suggests ALA may reduce weight gain associated with use of antipsychotic drugs.

C Wound healing in people undergoing hyperbaric oxygen therapy ALA may reduce tissue damage caused by long-term exposure to high levels of oxygen. C Alcoholic liver disease ALA has been studied as a treatment for alcohol-related liver disease.

For bone density, milligrams of ALA has been taken by mouth twice daily for 12 months. For high blood pressure, milligrams of ALA has been taken by mouth daily for eight weeks.

For inflammation, milligrams of ALA has been taken by mouth for up to three months. For kidney disease, milligrams of ALA has been taken by mouth daily for weeks.

For migraine, milligrams of ALA has been taken by mouth daily for three months. You might be wondering, how does it work? Alpha Lipoic Acid is a powerful antioxidant that is fat soluble. Antioxidants lessen or neutralize the effect of free radicals.

Free radicals are a byproduct or waste of metabolic processes and even more free radicals are produced when fighting an infection or exposure to pollution to name a few. When we have an imbalance where there are more free radicals than antioxidants, our body undergoes oxidative stress, which causes damage and inflammation, and in this particular case at the nervous system.

An infusion of Alpha Lipoic Acid gives the body the antioxidants it needs to restore the balance and clear free radicals to prevent further destruction and even reverse the damage done.

Again, Alpha Lipoic Acid is particularly good for the nervous system over other antioxidants because it easily passes into the brain and the nerve tissues. If you are experiencing neuropathy secondary to diabetes, then Alpha Lipoic Acid has even more benefit!

Intravenous Alpha Lipoic Acid can decrease blood sugar levels and increase insulin sensitivity. A recent meta-analysis comprising 1, diabetic patients with symptomatic DSP from four randomized clinical trials 14 including the first Symptomatic Diabetic Neuropathy SYDNEY study 15 suggested that treatment with ALA using mg i.

as a daily infusion for 3 weeks reduced pain, paresthesia, and numbness to a clinically meaningful degree. This effect was accompanied by an improvement of neuropathic deficits, assuming a potential of the drug to favorably influence the underlying neuropathy. However, apart from a small oral pilot study ORPIL using mg ALA t.

d 16 , the efficacy and dose response of oral treatment with ALA on neuropathic symptoms and deficits in patients with symptomatic DSP have not yet been established. Therefore, we conducted a four-arm, randomized, double-blind, placebo-controlled, dose-response trial using ALA , 1,, and 1, mg q.

treatment over 5 weeks after a 1-week placebo run-in period. The SYDNEY 2 trial was a four-arm, parallel group, randomized, double-blind, placebo-controlled, multicenter trial using three oral doses of ALA Thioctacid HR; MEDA Pharma, Bad Homburg, Germany.

The primary end point was a confirmatory comparison of each group receiving ALA versus placebo using the change in Total Symptom Score TSS from baseline. After obtaining the approvals by the Ethics Committees of Hadassah University, Jerusalem, Israel, and the Wolfson Medical Center, Holon, Israel, and the National Ethics Committee of the Ministry of Health, Moscow, Russia, and written informed consent, patients with diabetes and symptomatic DSP were recruited from two centers in Israel and three centers in Russia.

All patients were exposed to once-daily placebo treatment for 1 week single-blind run-in phase. Thereafter, eligible patients were randomly assigned to receive the following treatments once daily over 5 consecutive weeks: ALA mg ALA , 1, mg ALA , 1, mg ALA , or placebo double-blind treatment phase.

A 5-week treatment duration was chosen because, in previous studies, no plateau in the TSS response was observed after 3 weeks of intravenous ALA treatment and a slower onset of efficacy was assumed for oral therapy.

The TSS was assessed at screening, at baseline before start of study treatment, and after 1, 2, 3, 4, and 5 weeks of treatment. All other parameters see below were determined at screening and at the end of the study.

The NIS and the Neuropathy Symptoms and Change NSC score were assessed according to the Clinical Neuropathic Assessment as previously described The NSC scores number, severity, and change are derived from answers to 38 questions muscle weakness, questions 1—19; sensation, questions 20—29; and autonomic symptoms, questions 30—38 Moreover, nerve conduction studies amplitude, velocity, and latency of the tibial and peroneal nerves and amplitude and latency of the sural nerve were performed.

All neurological assessments were done by trained and certified neurologists. All answered Clinical Neuropathic Assessment booklets were reviewed by the Reading and Quality Assurance Center at the Mayo Clinic, Rochester, Minnesota. DSP was staged according to Dyck et al.

Adverse events were monitored throughout the entire study. The confirmatory analysis was based on the comparison of the changes in TSS from baseline to the end of treatment among the ALA groups and placebo including center effects but no treatment-center interactions. A treatment difference of 1.

For all efficacy variables, the analyses of the intention-to-treat population were primary. To reduce variance, ANCOVA was applied with the baseline as covariate. In the case of missing data for study end week 5 , the last value carried forward principle was applied.

To determine the onset of action, each time point was analyzed analogously to the primary analysis. Among the secondary variables, the subscores of the TSS and NSC scores were analyzed in analogy to the confirmatory analysis.

Thus, patients entered the run-in phase. Among these, six patients were not randomly assigned because of unstable TSS or withdrawal of consent. Most patients 12 discontinued because of adverse events: 1 in the placebo group, 0 in the ALA group, 5 in ALA, and 6 in ALA One patient in the ALA group did not complete the trial because of lack of efficacy; another one patient each in the ALAand ALA group discontinued for other reasons.

The clinical characteristics of the patients are shown in Table 1. There were also no significant differences among the groups in the mean baseline TSS and its individual subscores. No significant differences among the three ALA groups and the placebo group were noted for paresthesia and numbness.

The mean TSS levels during the placebo run-in and the randomized double-blind period of the trial are illustrated in Fig. No significant differences were observed among the three ALA groups for the changes in mean TSS at any of the time points examined.

The mean levels of the NSC scores, NIS, and NIS [LL] at screening and their changes after 5 weeks of treatment are given in Table 3. There were no significant differences among the groups at screening.

No significant differences among the groups were noted for any of the nerve conduction studies data not shown. The results of the SYDNEY 2 trial demonstrate that oral treatment with ALA over 5 weeks improved the positive sensory symptoms scored by the TSS in diabetic patients with DSP.

This overall effect was not dose dependent, as there were no differences in the changes in mean TSS among all active groups. A significant improvement in TSS was noted as soon as after 1 week with ALA and after 2 weeks with ALA and ALA Among the individual TSS symptoms, improvement in pain but not paresthesia and numbness was observed.

Moreover, ALA ameliorated the NSC and neuropathy impairment scores NIS and NIS [LL]. The mechanisms of the rapid improvement in both neuropathic symptoms and deficits may be related to an improvement in nerve blood flow mediated by the antioxidant action of ALA 19 — This effect was accompanied by reductions in plasma levels of interleukin-6 and plasminogen activator-1, suggesting that the drug may improve endothelial dysfunction via anti-inflammatory and antithrombotic mechanisms Intravenous infusion of mg ALA exerts an acute effect on microcirculation in patients with diabetic polyneuropathy 28 , The impairment of nitric oxide—mediated vasodilation in diabetes has been attributed to increased vascular oxidative stress.

At this point, acute infusion of ALA improved nitric oxide—mediated endothelium-dependent vasodilation in diabetic patients The safety analysis revealed an overall favorable safety profile for the low dose.

The most frequent adverse event was a dose-dependent increase in the incidence of nausea. and 1, mg q. The rate of adverse events with 1, mg q. intravenously However, a direct comparison of these studies is not possible because of the different routes of administration and oral drug formulations used.

Alpha-lipoic acid ALA is Alpha-lipokc naturally in the nervee and may protect against cell damage in Carb counting app suggestions variety of negve. Food Soccer nutrition tips rich in alpha-lipoic acid include spinach, Alpha-lipoic acid for nerve pain, Alpha-lipooc yeast. ALA, known Cranberry holiday cocktails the "universal oxidant," has Alppha-lipoic used Alpha-liplic decades in Europe to treat nerve conditions, including nerve damage resulting from poorly controlled diabetes. There is strong evidence that ALA may help treat type 2 diabetes and neuropathy. According to a survey of herbalists, ALA was one of the 10 most frequently recommended dietary supplements due to its efficacy in reducing high blood sugar levels. There are not enough data to support the use of ALA in Amanita poisoning a poisonous mushroom that causes liver damagewhich has reportedly been a common practice for many years. Dan ZieglerAlexander AmetovAlexey Barinov Soccer nutrition tips, Peter J. Promoting self-care in diabetes wellnessIrina GurievaPhillip A. LowUllrich Alphq-lipoicNikolai YakhnoItamar RazMaria NervsJoachim Maus Soccer nutrition tips, Alpha-lipokc Samigullin; Oral Treatment With α-Lipoic Acid Paib Symptomatic Soccer nutrition tips Polyneuropathy : The SYDNEY 2 trial. Diabetes Care 1 November ; 29 11 : — OBJECTIVE —The aim of this trial was to evaluate the effects of α-lipoic acid ALA on positive sensory symptoms and neuropathic deficits in diabetic patients with distal symmetric polyneuropathy DSP. The primary outcome measure was the change from baseline of the Total Symptom Score TSSincluding stabbing pain, burning pain, paresthesia, and asleep numbness of the feet. RESULTS —Mean TSS did not differ significantly at baseline among the treatment groups and on average decreased by 4.

Alpha-lipoic acid for nerve pain -

Additional studies on this topic are needed. Diabetes is a serious illness and should be treated under the supervision of a qualified healthcare provider.

Antioxidants that included ALA had mixed effects on altitude sickness. Additional research is needed on ALA alone. Early research shows mixed results regarding ALA for brain protection. Additional research on this topic is needed. ALA may increase the production of glutathione and help repair cell damage.

Most studies support the antioxidant effects of ALA. Additional research is needed in this area. Overall evidence of ALA for improving bone mineral density is lacking, although ALA has increased density in a specific hip bone. Further research is needed. Early research suggests that alpha-lipoic acid with other antioxidants may improve weight loss from cancer.

Studies evaluating ALA alone are needed. Overall evidence of ALA for preventing cancer progression is currently lacking. Early research suggests that ALA and gamma-linolenic acid may benefit symptoms of carpal tunnel syndrome, particularly in the early stages of the disease.

Additional research evaluating ALA alone is needed. ALA has been studied as a treatment for cognitive impairment problems with mental function caused by nerve damage in HIV patients.

More high-quality studies are needed. ALA may protect the eye from excess pressure, but more research is needed to evaluate ALA's long-term effect. In early research, ALA and other antioxidants had mixed effects on blood pressure. The effects of ALA alone are unclear, and further research is needed.

Antioxidants that included ALA improved some measurements of blood flow. Further research is needed on ALA alone. Early research shows that antioxidants, including ALA, may benefit people undergoing cardiac surgery. In people with impaired glucose tolerance, ALA had mixed results in improving insulin levels and the insulin response.

Further research is needed on this topic. In HIV patients on antiretroviral therapy, ALA improved white blood cell function. ALA has shown mixed results for improving blood flow. The effects of ALA on inflammation markers are unclear.

Ischemia-reperfusion injury protection prevention of tissue damage after restored blood flow. ALA may prevent tissue damage after restored blood flow in the liver. ALA may improve the blood vessel lining function, possibly benefiting patients with end-stage kidney disease.

More research is needed in this area. Research investigating the effect of ALA for mitochondrial diseases problems with cell energy is limited.

Further research is required. ALA has shown mixed results as a treatment for burning mouth syndrome, a condition that causes the mouth to feel hot or tingly.

Additional research is needed. ALA may reduce pain associated with exercise in people with peripheral artery disease. Additional studies are warranted.

Limited research suggests that ALA may be beneficial for people exposed to high levels of radiation. Well-designed studies are needed. Early research suggests that ALA acid lacks effects on symptoms of rheumatoid arthritis and inflammatory mediators.

Early research suggests that ALA may reduce some adverse effects of antipsychotic drugs. Additional high-quality studies are needed. The antioxidant effects of ALA may aid recovery of nerve function and pain reduction. Early research shows that a skin cream with ALA may help improve signs of skin aging.

Antioxidants with ALA may improve the effectiveness of treatment for skin pigmentation. ALA may reduce liver size and reduce other symptoms of a fatty liver. More well-designed studies are needed. Research suggests ALA may reduce weight gain associated with use of antipsychotic drugs.

ALA may reduce tissue damage caused by long-term exposure to high levels of oxygen. ALA has been studied as a treatment for alcohol-related liver disease. However, benefits have not been observed at this time. For alcoholic liver disease, milligrams of ALA has been taken by mouth in three divided doses daily for up to 24 weeks.

As an antioxidant, , milligrams of ALA has been taken by mouth daily for four weeks to six months. Additionally, , milligrams of ALA has been taken by mouth in two or three divided doses for days.

For cognitive function associated with HIV, milligrams of ALA has been taken by mouth twice daily for 10 weeks. For glaucoma damaged optic nerve , milligrams of ALA taken by mouth for one month showed improvement over 75 milligrams of ALA taken by mouth for two months.

For HIV patients on antiretroviral therapy, milligrams of ALA has been taken by mouth three times daily for six months. For impaired glucose tolerance, milliliters of saline solution containing milligrams of ALA was injected once daily for up to three weeks.

Additionally, milliliters of saline containing milligrams of ALA has been used as a single dose. For improving blood flow, , milligrams of ALA has been taken by mouth.

Additionally, milligrams of ALA in milliliters of saline has been injected for up to three weeks. For lipid lowering effects, milligrams of ALA has been taken by mouth daily for up to16 weeks. A dosage of milligrams was also taken by mouth daily for four weeks.

A dosage of milligrams of ALA in milliliters of saline has been injected into a vein daily for 14 days. For neuropathy nerve damage , , milligrams of ALA has been taken by mouth daily in divided doses from 19 days to four years. A dose of , milligrams of ALA has been injected into a vein for up to four weeks.

For pain burning mouth syndrome , milligrams of ALA has been taken by mouth daily for up to three months. For peripheral artery disease, milligrams of ALA has been taken by mouth daily in two divided doses for three months. For prevention of tissue damage after restored blood flow, milligrams of ALA in 50 milliliters of sodium chloride has been injected into a vein.

For rheumatoid arthritis, milligrams of ALA has been taken by mouth three times daily for 12 weeks. Researchers are investigating it as a potential treatment for stroke and other brain problems involving free radical damage, such as dementia.

So far, there's no evidence to say whether or not it works. Preliminary studies suggest alpha-lipoic acid may help treat glaucoma. But there is not enough evidence to say for sure whether it works. Studies show ALA binds with toxic metals, such as mercury, arsenic, iron, and other metals that act as free radicals.

Preliminary studies also suggest that ALA may play a role in managing other conditions including erectile dysfunction and cancer. And preliminary studies suggest it may reduce complications associated with otitis media ear infections. If you are healthy, your body makes enough alpha-lipoic acid.

It is also found in red meat, organ meats such as liver , and yeast -- particularly brewer's yeast. Alpha-lipoic acid supplements are available as capsules.

Your health care provider can also give it by injection. Pediatric Alpha-lipoic acid has not been studied in children, so it is not recommended for pediatric use. Check with your doctor regarding dosing recommendations. Studies are mixed about whether or not to take ALA with meals.

Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a health care provider. Alpha-lipoic acid hasn't been studied in pregnant or breastfeeding women, so researchers don't know if it's safe.

Alpha-lipoic acid can lower blood sugar levels, so people with diabetes or low blood sugar should take alpha-lipoic acid only under the supervision of their health care provider. Animal studies suggest that people who don't get enough thiamine vitamin B1 should not take alpha-lipoic acid.

B1 deficiency is associated with long-term alcohol abuse. If you are being treated with any of the following medications, you should not use alpha-lipoic acid without first talking to your health care provider.

Apha-lipoic acid can combine with these drugs to lower blood sugar levels, raising the risk of hypoglycemia or low blood sugar. Ask your provider before taking alpha-lipoic acid, and watch your blood sugar levels closely.

Your provider may need to adjust your medication doses. Alpha-lipoic acid may interfere with some chemotherapy medications.

Always ask your oncologist before taking any herb or supplement, including alpha-lipoic acid. Apha-lipoic acid may lower levels of thyroid hormone. Your provider should monitor blood hormone levels and thyroid function tests closely. Alpha lipoic acid can lower the level of vitamin B1 Thiamine in the body.

This can be particularly dangerous in alcoholics where malnutrition is often already present. Androne L, Gavan NA, Veresiu IA, Orasan R. In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo. Beitner H.

Br J Dermatol. Berkson BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid thioctic acid , silymarin, and selenium: three case histories. Med Klin. Clark WM, Rinker LG, Lessov NS, Lowery SL, Cipolla MJ.

Efficacy of antioxidant therapies in transient focal ischemia in mice. Faust A, Burkart V, Ulrich H, et al. Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice. Int J Immunopharmacol.

Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev. Hruby K, Csomos G, Fuhrmann M, Thaler H. Increasing bioavailability of R -alpha-lipoic acid to boost antioxidant activity in the treatment of neuropathic pain.

Breithaupt-Grogler K, Niebch G, Schneider E, et al. Dose-proportionality of oral thioctic acid--coincidence of assessments via pooled plasma and individual data.

Evans JL, Heymann CJ, Goldfine ID, Gavin LA. Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid. Endocr Pract. Keith DJ, Butler JA, Bemer B, et al. Age and gender dependent bioavailability of R- and R,S-alpha-lipoic acid: a pilot study.

Pharmacol Res. Hiltunen JK, Autio KJ, Schonauer MS, Kursu VA, Dieckmann CL, Kastaniotis AJ. Mitochondrial fatty acid synthesis and respiration. Biochim Biophys Acta. Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH.

Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med. Jones W, Li X, Qu ZC, Perriott L, Whitesell RR, May JM.

Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells. Kozlov AV, Gille L, Staniek K, Nohl H. Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone.

Arch Biochem Biophys. May JM, Qu ZC, Mendiratta S. Protection and recycling of alpha-tocopherol in human erythrocytes by intracellular ascorbic acid. Upston JM, Terentis AC, Stocker R. Tocopherol-mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement.

Faseb J. Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Doraiswamy PM, Finefrock AE. Metals in our minds: therapeutic implications for neurodegenerative disorders. Lancet Neurol. Ou P, Tritschler HJ, Wolff SP. Thioctic lipoic acid: a therapeutic metal-chelating antioxidant?

Biochem Pharmacol. Suh JH, Zhu BZ, deSzoeke E, Frei B, Hagen TM. Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes.

Redox Rep. Suh JH, Moreau R, Heath SH, Hagen TM. Dietary supplementation with R -alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.

Yamamoto H, Watanabe T, Mizuno H, et al. The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon LEC rats. Free Radic Res. Patrick L. Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity.

Altern Med Rev. Rooney JP. The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Hagen TM, Vinarsky V, Wehr CM, Ames BN. R -alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo.

Antioxid Redox Signal. Busse E, Zimmer G, Schopohl B, Kornhuber B. Influence of alpha-lipoic acid on intracellular glutathione in vitro and in vivo. Monette JS, Gomez LA, Moreau RF, et al. R -alpha-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria.

Suh JH, Shenvi SV, Dixon BM, et al. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.

Proc Natl Acad Sci U S A. Suh JH, Wang H, Liu RM, Liu J, Hagen TM. R -alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis.

Zhang J, Zhou X, Wu W, Wang J, Xie H, Wu Z. Environ Toxicol Pharmacol. Fratantonio D, Speciale A, Molonia MS, et al. Alpha-lipoic acid, but not di-hydrolipoic acid, activates Nrf2 response in primary human umbilical-vein endothelial cells and protects against TNF-alpha induced endothelium dysfunction.

Sena CM, Cipriano MA, Botelho MF, Seica RM. Lipoic acid prevents high-fat diet-induced hepatic steatosis in Goto Kakizaki rats by reducing oxidative stress through Nrf2 activation.

Int J Mol Sci. Pilar Valdecantos M, Prieto-Hontoria PL, Pardo V, et al. Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. Fayez AM, Zakaria S, Moustafa D. Biomed Pharmacother. Lin YC, Lai YS, Chou TC.

The protective effect of alpha-lipoic Acid in lipopolysaccharide-induced acute lung injury is mediated by heme oxygenase Evid Based Complement Alternat Med. Segal AW. The function of the NADPH oxidase of phagocytes and its relationship to other NOXs in plants, invertebrates, and mammals.

Int J Biochem Cell Biol. Dong Y, Wang H, Chen Z. Int J Endocrinol. Byun E, Lim JW, Kim JM, Kim H. alpha-Lipoic acid inhibits Helicobacter pylori-induced oncogene expression and hyperproliferation by suppressing the activation of NADPH oxidase in gastric epithelial cells.

Mediators Inflamm. Konrad D. Utilization of the insulin-signaling network in the metabolic actions of alpha-lipoic acid-reduction or oxidation? Diesel B, Kulhanek-Heinze S, Holtje M, et al. Alpha-lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis.

Estrada DE, Ewart HS, Tsakiridis T, et al. Yaworsky K, Somwar R, Ramlal T, Tritschler HJ, Klip A. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes.

Ying Z, Kampfrath T, Sun Q, Parthasarathy S, Rajagopalan S. Evidence that alpha-lipoic acid inhibits NF-kappaB activation independent of its antioxidant function. Inflamm Res. Smith AR, Hagen TM.

Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by R -alpha-lipoic acid. Biochem Soc Trans. Wang Y, Li X, Guo Y, Chan L, Guan X. alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice.

Moura FA, de Andrade KQ, dos Santos JC, Goulart MO. Lipoic acid: its antioxidant and anti-inflammatory role and clinical applications.

Curr Top Med Chem. Packer L, Cadenas E. Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. J Clin Biochem Nutr. Rochette L, Ghibu S, Richard C, Zeller M, Cottin Y, Vergely C. Direct and indirect antioxidant properties of alpha-lipoic acid and therapeutic potential.

Mol Nutr Food Res. Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Mayr JA, Zimmermann FA, Fauth C, et al. Lipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation.

Am J Hum Genet. Tort F, Ferrer-Cortes X, Thio M, et al. Mutations in the lipoyltransferase LIPT1 gene cause a fatal disease associated with a specific lipoylation defect of the 2-ketoacid dehydrogenase complexes.

Hum Mol Genet. Ziegler D. Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review. Treat Endocrinol. Nathan DM, Davidson MB, DeFronzo RA, et al. Impaired fasting glucose and impaired glucose tolerance: implications for care.

Diabetes Care. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid.

Jacob S, Rett K, Henriksen EJ, Haring HU. Thioctic acid--effects on insulin sensitivity and glucose-metabolism. de Oliveira AM, Rondo PH, Luzia LA, D'Abronzo FH, Illison VK. The effects of lipoic acid and alpha-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial.

Diabetes Res Clin Pract. Akbari M, Ostadmohammadi V, Lankarani KB, et al. The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials.

Roberts AC, Porter KE. Cellular and molecular mechanisms of endothelial dysfunction in diabetes. Diab Vasc Dis Res. Heitzer T, Finckh B, Albers S, Krohn K, Kohlschutter A, Meinertz T.

Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress.

Heinisch BB, Francesconi M, Mittermayer F, et al. Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. Eur J Clin Invest. Xiang G, Pu J, Yue L, Hou J, Sun H. alpha-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose.

Xiang GD, Sun HL, Zhao LS, Hou J, Yue L, Xu L. The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance. Clin Endocrinol Oxf.

Sola S, Mir MQ, Cheema FA, et al. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction ISLAND study.

National Institute of Diabetes and Digestive and Kidney Diseases. Diabetic Neuropathy. Malik RA, Tesfaye S, Ziegler D. Medical strategies to reduce amputation in patients with type 2 diabetes. Diabet Med. Obrosova IG. Diabetes and the peripheral nerve. Dy SM, Bennett WL, Sharma R, et al.

AHRQ Comparative Effectiveness Reviews. Preventing complications and treating symptoms of diabetic peripheral neuropathy. Rockville MD : Agency for Healthcare Research and Quality US ; The Diabetes Control and Complications Trial Research Group.

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med.

UK Prospective Diabetes Study UKPDS Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes UKPDS Callaghan BC, Little AA, Feldman EL, Hughes RA. Enhanced glucose control for preventing and treating diabetic neuropathy.

Cochrane Database Syst Rev. Han T, Bai J, Liu W, Hu Y. A systematic review and meta-analysis of alpha-lipoic acid in the treatment of diabetic peripheral neuropathy.

Eur J Endocrinol. Ruhnau KJ, Meissner HP, Finn JR, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid alpha-lipoic acid in symptomatic diabetic polyneuropathy. Ziegler D, Hanefeld M, Ruhnau KJ, et al.

Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial ALADIN III Study. ALADIN III Study Group. Alpha-lipoic acid in diabetic neuropathy. Ziegler D, Ametov A, Barinov A, et al.

Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial.

Compact by Design Soccer nutrition tips neeve Amazon Alpha-lipooic remove excess air and water, which reduces the Appha-lipoic footprint of shipping Maintaining a healthy weight packaging. All Nervive products are Antidepressant for PMS free and only 1 tablet needed per day; day supply included. Try Nervive Nerve Relief and see how you can get back to living your life how you want to. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE. Click to play video. A Magical Mess.

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